Programm Advances in Therapeutic Approaches

Session 1 - Targeted Protein Degradation (Session chair: Ivan Đikić)

Aimo Kannt - Welcome and Introduction (12:50)

Radosław Nowak - Targeting C2H2 transcription factors for degradation with molecular glues (13:00)

Bhavesh Parmar - Time-resolved high-throughput proteomics to understand the dynamics of protein degradation (13:35)

Nicolas Thomä - Oncogenic transcription factors, and how to get rid of them (14:00)

Sarah Köllner - The Sorting Games: Sortilin-targeting degraders (14:35)

Varun Shah - Discovery of Novel Molecular Glue Degraders (15:00)

Martin Schwalm - Functional live-cell systems to test inhibitors targeting the ubiquitin-proteasome system (15:15)

Kaffeepause (15:30 - 16:15)

Session 2 - Technology Advances: from imaging to computational approaches (Session chair: Maike Windbergs)

Andrea Ablasser - Innate immune sensing of DNA as a danger signal (16.15) 

James Cranley - What can cell atlases teach us about human cardiovascular disease? (16:50)

Stefanie Kaiser - Advancing RNA analysis in the context of therapy (17:25)

Im Anschluss an den wissenschaftlichen Teil besteht die Möglichkeit sich bei einem Get-together bei Fingerfood auszutauschen. 

Session 3 - RNA-based therapeutics (Session chair: Christian Münch)

Welcome and Coffee (8:45)

Mustafa Diken - mRNA vaccines against cancer (9:00)

Maike Windbergs - Overcoming biological barriers in the human body by tailor-made nanocarriers (9:35)

Mathias Munschauer - An RNA-centric perspective on viral infections  (10:10)

Harald Schwalbe - New ways to target new targets - focus on fragment screening (10:45)

Anna Wacker - Targeting viral RNAs with small molecules (11:20)

Mittagspause (ca. 60 min)

Session 4 - Targeting common mechanisms of human diseases (Session chair: Aimo Kannt)

Uxía Gestal-Mato - Tumor immune evasion through IRGQ-directed autophagy (12:45)

Krishnaraj Rajalingam - Targeting the two co-conspirators RAS and C-MYC in cancer (13:10)

Maria Vehreschild - Modulating the human gut microbiota for therapeutic purposes (13:45)

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